Structural mechanism underlying capsaicin binding and activation of TRPV1 ion channel

Capsaicin bestows spiciness by activating TRPV1 channel with exquisite potency and selectivity. Capsaicin-bound channel structure was previously resolved by cryo-EM at 4.2-to-4.5 Å resolution, however important details required for mechanistic understandings are unavailable: capsaicin was registered...

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Detalles Bibliográficos
Autores principales: Yang, Fan, Xiao, Xian, Cheng, Wei, Yang, Wei, Yu, Peilin, Song, Zhenzhen, Yarov-Yarovoy, Vladimir, Zheng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472570/
https://www.ncbi.nlm.nih.gov/pubmed/26053297
http://dx.doi.org/10.1038/nchembio.1835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472570/
https://www.ncbi.nlm.nih.gov/pubmed/26053297
http://dx.doi.org/10.1038/nchembio.1835

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