TSH-Mediated TNFα Production in Human Fibrocytes Is Inhibited by Teprotumumab, an IGF-1R Antagonist

PURPOSE: Fibrocytes (FC) are bone marrow-derived progenitor cells that are more abundant and infiltrate the thyroid and orbit in Graves orbitopathy (GO). FCs express high levels of thyrotropin receptor (TSHR) and insulin-like growth factor-1 receptor (IGF-1R). These receptors are physically and func...

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Detalles Bibliográficos
Autores principales: Chen, Hong, Shan, Shannon J. C., Mester, Tünde, Wei, Yi-Hsuan, Douglas, Raymond S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472723/
https://www.ncbi.nlm.nih.gov/pubmed/26087256
http://dx.doi.org/10.1371/journal.pone.0130322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472723/
https://www.ncbi.nlm.nih.gov/pubmed/26087256
http://dx.doi.org/10.1371/journal.pone.0130322

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