Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy

Unbalanced (major route) additional cytogenetic aberrations (ACA) at diagnosis of chronic myeloid leukemia (CML) indicate an increased risk of progression and shorter survival. Moreover, newly arising ACA under imatinib treatment and clonal evolution are considered features of acceleration and defin...

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Detalles Bibliográficos
Autores principales: Haaß, Wiltrud, Kleiner, Helga, Weiß, Christel, Haferlach, Claudia, Schlegelberger, Brigitte, Müller, Martin C., Hehlmann, Rüdiger, Hofmann, Wolf-Karsten, Fabarius, Alice, Seifarth, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472749/
https://www.ncbi.nlm.nih.gov/pubmed/26087013
http://dx.doi.org/10.1371/journal.pone.0129648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472749/
https://www.ncbi.nlm.nih.gov/pubmed/26087013
http://dx.doi.org/10.1371/journal.pone.0129648

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