Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin

In myeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phosphorylated in response to LPS. To investigate the role of two specific phosphorylations, at serines 52 and 178, we created a mouse strain in which those residues were replaced by nonphosphorylatable...

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Detalles Bibliográficos
Autores principales: Ross, Ewan A., Smallie, Tim, Ding, Qize, O’Neil, John D., Cunliffe, Helen E., Tang, Tina, Rosner, Dalya R., Klevernic, Iva, Morrice, Nicholas A., Monaco, Claudia, Cunningham, Adam F., Buckley, Christopher D., Saklatvala, Jeremy, Dean, Jonathan L., Clark, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2015
Materias:
Innate Immunity and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472942/
https://www.ncbi.nlm.nih.gov/pubmed/26002976
http://dx.doi.org/10.4049/jimmunol.1402826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472942/
https://www.ncbi.nlm.nih.gov/pubmed/26002976
http://dx.doi.org/10.4049/jimmunol.1402826

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