Thiol-free reducing agents in electrophoretic separations and FASP proteolytic digestions for the analysis of metal-binding proteins

The analysis of the complexes between metal-based chemotherapeutic drugs and proteins in biological samples, such as cisplatin or oxaliplatin, can be a challenge due to metal strong reactivity towards S-donor molecules such as dithiothreitol (DTT) or β-mercaptoethanol (BME), usually employed as redu...

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Detalles Bibliográficos
Autores principales: Moraleja, I., Moreno-Gordaliza, E., Mena, M.L., Gómez-Gómez, M.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472949/
https://www.ncbi.nlm.nih.gov/pubmed/26150950
http://dx.doi.org/10.1016/j.mex.2014.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472949/
https://www.ncbi.nlm.nih.gov/pubmed/26150950
http://dx.doi.org/10.1016/j.mex.2014.08.003

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