Ion channel regulation by phosphoinositides analyzed with VSPs—PI(4,5)P(2) affinity, phosphoinositide selectivity, and PI(4,5)P(2) pool accessibility

The activity of many proteins depends on the phosphoinositide (PI) content of the membrane. E.g., dynamic changes of the concentration of PI(4,5)P(2) are cellular signals that regulate ion channels. The susceptibility of a channel to such dynamics depends on its affinity for PI(4,5)P(2). Yet, measur...

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Detalles Bibliográficos
Autores principales: Rjasanow, Alexandra, Leitner, Michael G., Thallmair, Veronika, Halaszovich, Christian R., Oliver, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472987/
https://www.ncbi.nlm.nih.gov/pubmed/26150791
http://dx.doi.org/10.3389/fphar.2015.00127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472987/
https://www.ncbi.nlm.nih.gov/pubmed/26150791
http://dx.doi.org/10.3389/fphar.2015.00127

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