Model-Based Assessment of Dosing Strategies in Children for Monoclonal Antibodies Exhibiting Target-Mediated Drug Disposition

Body weight/body surface area–based and/or tiered fixed dosing strategies are widely utilized for monoclonal antibodies with linear clearance to scale adult clinical doses to children. However, there is limited knowledge on whether or not body weight–based dosing strategies also yield comparable dos...

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Detalles Bibliográficos
Autores principales: Zheng, S, Gaitonde, P, Andrew, M A, Gibbs, M A, Lesko, L J, Schmidt, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474168/
https://www.ncbi.nlm.nih.gov/pubmed/25271939
http://dx.doi.org/10.1038/psp.2014.38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474168/
https://www.ncbi.nlm.nih.gov/pubmed/25271939
http://dx.doi.org/10.1038/psp.2014.38

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