Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists

Toll-like receptor (TLR) agonists activate both the innate and the adaptive immune systems. These TLR agonists have been exploited as potent vaccine adjuvants and antitumor agents. We describe the identification and characterization of a small molecule, N-methyl-4-nitro-2-(4-(4-(trifluoromethyl)phen...

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Detalles Bibliográficos
Autores principales: Cheng, Kui, Gao, Meng, Godfroy, James I., Brown, Peter N., Kastelowitz, Noah, Yin, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474499/
https://www.ncbi.nlm.nih.gov/pubmed/26101787
http://dx.doi.org/10.1126/sciadv.1400139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474499/
https://www.ncbi.nlm.nih.gov/pubmed/26101787
http://dx.doi.org/10.1126/sciadv.1400139

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