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Tetraploid Embryonic Stem Cells Maintain Pluripotency and Differentiation Potency into Three Germ Layers
Polyploid amphibians and fishes occur naturally in nature, while polyploid mammals do not. For example, tetraploid mouse embryos normally develop into blastocysts, but exhibit abnormalities and die soon after implantation. Thus, polyploidization is thought to be harmful during early mammalian develo...
Autores principales: | Imai, Hiroyuki, Kano, Kiyoshi, Fujii, Wataru, Takasawa, Ken, Wakitani, Shoichi, Hiyama, Masato, Nishino, Koichiro, Kusakabe, Ken Takeshi, Kiso, Yasuo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474668/ https://www.ncbi.nlm.nih.gov/pubmed/26091100 http://dx.doi.org/10.1371/journal.pone.0130585 |
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