Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport

Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia (AML), where mutant NPM seems to play an oncogenic role. AML-associated NPM mu...

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Detalles Bibliográficos
Autores principales: Arregi, Igor, Falces, Jorge, Olazabal-Herrero, Anne, Alonso-Mariño, Marián, Taneva, Stefka G., Rodríguez, José A., Urbaneja, María A., Bañuelos, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474691/
https://www.ncbi.nlm.nih.gov/pubmed/26091065
http://dx.doi.org/10.1371/journal.pone.0130610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474691/
https://www.ncbi.nlm.nih.gov/pubmed/26091065
http://dx.doi.org/10.1371/journal.pone.0130610

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