Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation

Dicer, a ribonuclease III enzyme, is required for the maturation of microRNAs. To assess its role in cerebellar and medulloblastoma development, we genetically deleted Dicer in Nestin-positive neural progenitors and in mice lacking one copy for the Sonic Hedgehog receptor, Patched 1. We found that c...

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Detalles Bibliográficos
Autores principales: Zindy, Frederique, Lee, Youngsoo, Kawauchi, Daisuke, Ayrault, Olivier, Merzoug, Leila Ben, Li, Yang, McKinnon, Peter J., Roussel, Martine F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474721/
https://www.ncbi.nlm.nih.gov/pubmed/26091048
http://dx.doi.org/10.1371/journal.pone.0129642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474721/
https://www.ncbi.nlm.nih.gov/pubmed/26091048
http://dx.doi.org/10.1371/journal.pone.0129642

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