Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin

OBJECTIVE: Blood brain barrier (BBB) breakdown and increased endothelial permeability is a hallmark of neuro-vascular inflammation. Angiopoietin-1 (Ang-1), a Tie-2 receptor agonist ligand, is known to modulate barrier function of endothelial cells; however the molecular mechanisms related to Ang-1 m...

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Detalles Bibliográficos
Autores principales: Siddiqui, M. Rizwan, Mayanil, Chandra S., Kim, Kwang Sik, Tomita, Tadanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474807/
https://www.ncbi.nlm.nih.gov/pubmed/26090670
http://dx.doi.org/10.1371/journal.pone.0130857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474807/
https://www.ncbi.nlm.nih.gov/pubmed/26090670
http://dx.doi.org/10.1371/journal.pone.0130857

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