Cargando…

Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin

OBJECTIVE: Blood brain barrier (BBB) breakdown and increased endothelial permeability is a hallmark of neuro-vascular inflammation. Angiopoietin-1 (Ang-1), a Tie-2 receptor agonist ligand, is known to modulate barrier function of endothelial cells; however the molecular mechanisms related to Ang-1 m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siddiqui, M. Rizwan, Mayanil, Chandra S., Kim, Kwang Sik, Tomita, Tadanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474807/ https://www.ncbi.nlm.nih.gov/pubmed/26090670 http://dx.doi.org/10.1371/journal.pone.0130857

Ejemplares similares

Erythropoietin-mediated activation of aquaporin-4 channel for the treatment of experimental hydrocephalus
por: Rizwan Siddiqui, M., et al.
Publicado: (2018)

TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK
por: Ni, Yawen, et al.
Publicado: (2017)

Amyloid-β-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation
por: Tai, L M, et al.
Publicado: (2010)

pTyr(421) Cortactin Is Overexpressed in Colon Cancer and Is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1)
por: Radhakrishnan, Vijayababu M., et al.
Publicado: (2014)

Protein tyrosine phosphatase PTPN21 acts as a negative regulator of ICAM-1 by dephosphorylating IKKβ in TNF-α-stimulated human keratinocytes
por: Cho, Young-Chang, et al.
Publicado: (2017)

Opposing Effects of the Angiopoietins on the Thrombin-Induced Permeability of Human Pulmonary Microvascular Endothelial Cells
por: van der Heijden, Melanie, et al.
Publicado: (2011)

Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx
por: Salmon, Andrew H.J., et al.
Publicado: (2009)

Recombinant Human Sonic Hedgehog Protein Regulates the Expression of ZO-1 and Occludin by Activating Angiopoietin-1 in Stroke Damage
por: Xia, Yuan-peng, et al.
Publicado: (2013)

Cleavage of Occludin by Cigarette Smoke-Elicited Cathepsin S Increases Permeability of Lung Epithelial Cells
por: Bigot, Paul, et al.
Publicado: (2022)

Protein Kinase Cβ Phosphorylates Occludin Regulating Tight Junction Trafficking in Vascular Endothelial Growth Factor–Induced Permeability In Vivo
por: Murakami, Tomoaki, et al.
Publicado: (2012)

Interaction between GPR110 (ADGRF1) and tight junction protein occludin implicated in blood-brain barrier permeability
por: Huang, Bill X., et al.
Publicado: (2023)

Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer
por: Mcheik, Soha, et al.
Publicado: (2020)

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
por: Spalinger, Marianne R., et al.
Publicado: (2023)

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier
por: Wong, Vivian, et al.
Publicado: (1997)

Endothelial permeability following coronary artery bypass grafting: an observational study on the possible role of angiopoietin imbalance
por: Hilbert, Tobias, et al.
Publicado: (2016)

PTPN2 targets TAK1 for dephosphorylation to improve cellular senescence and promote adipose tissue browning in T2DM
por: Liu, Yapeng, et al.
Publicado: (2023)

Occludin: a gatekeeper of brain Infection by HIV-1
por: Torices, Silvia, et al.
Publicado: (2023)

Novel regulation of Ras proteins by direct tyrosine phosphorylation and dephosphorylation
por: Buday, László, et al.
Publicado: (2020)

Progesterone decreases gut permeability through upregulating occludin expression in primary human gut tissues and Caco-2 cells
por: Zhou, Zejun, et al.
Publicado: (2019)

Activation of c-Src tyrosine kinase mediated the degradation of occludin in ventilator-induced lung injury
por: Zhao, Tao, et al.
Publicado: (2014)

Angiopoietin-2: Modulator of Vascular Permeability in Acute Lung Injury?
por: Hashimoto, Tomoki, et al.
Publicado: (2006)

Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
por: Liang, Xuan, et al.
Publicado: (2017)

Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis
por: Liu, Xia, et al.
Publicado: (2011)

The Tyrosine Phosphatase PTPN14 Is a Negative Regulator of YAP Activity
por: Michaloglou, Chrysiis, et al.
Publicado: (2013)

Reciprocal Regulation of C-Maf Tyrosine Phosphorylation by Tec and Ptpn22
por: Liu, Chih-Chun, et al.
Publicado: (2015)

Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, permeability, intercellular adhesion molecule-1, and occludin expression
por: Chen, Yi-Hui, et al.
Publicado: (2011)

Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
por: Sylvers-Davie, Kelli L., et al.
Publicado: (2021)

Tyrosine Dephosphorylation of H2AX Modulates Apoptosis and Survival Decisions
por: Cook, Peter J., et al.
Publicado: (2009)

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
Publicado: (1994)

Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface
por: Hansen, Tania M., et al.
Publicado: (2010)

The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation
por: Wang, Yubin, et al.
Publicado: (2017)

The FERM and PDZ Domain-Containing Protein Tyrosine Phosphatases, PTPN4 and PTPN3, Are Both Dispensable for T Cell Receptor Signal Transduction
por: Bauler, Timothy J., et al.
Publicado: (2008)

Scutellarin-treated exosomes increase claudin 5, occludin and ZO1 expression in rat brain microvascular endothelial cells
por: Zhong, Xiaoqin, et al.
Publicado: (2019)

Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2
por: Nguyen, Vicky PKH, et al.
Publicado: (2007)

Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6
por: Ueno, Yoshihisa, et al.
Publicado: (2015)

Prediction of Drug Permeability Using In Vitro Blood–Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells
por: Ohshima, Makiko, et al.
Publicado: (2019)

Occludin and connexin 43 expression contribute to the pathogenesis of traumatic brain edema
por: Ren, Wanyin, et al.
Publicado: (2013)

Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes
por: Mambwe, Bezaleel, et al.
Publicado: (2019)

Endocytosis takes occludin for a ride
por: Leslie, Mitch
Publicado: (2010)

Low Expression of Occludin in the Melanoma Patient
por: Salehi, Pouri, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_02rg23enfpna6rd46jnqfhuf6t