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A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer

BACKGROUND: Loss of the phosphatase and tensin homolog (PTEN) tumor suppressor gene is a promising marker of aggressive prostate cancer. Active surveillance and watchful waiting are increasingly recommended to patients with small tumors felt to be low risk, highlighting the difficulties of Gleason s...

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Detalles Bibliográficos
Autores principales: Troyer, Dean A, Jamaspishvili, Tamara, Wei, Wei, Feng, Ziding, Good, Jennifer, Hawley, Sarah, Fazli, Ladan, McKenney, Jesse K, Simko, Jeff, Hurtado-Coll, Antonio, Carroll, Peter R, Gleave, Martin, Lance, Raymond, Lin, Daniel W, Nelson, Peter S, Thompson, Ian M, True, Lawrence D, Brooks, James D, Squire, Jeremy A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475421/
https://www.ncbi.nlm.nih.gov/pubmed/25939393
http://dx.doi.org/10.1002/pros.23003