Novel Scaffolds of Cell-Active Histone Demethylase Inhibitors Identified from High-Throughput Screening

Jumonji C domain-containing histone demethylases (JHDMs) are epigenetic proteins capable of demethylating methylated lysine residues on histones proteins and for which high-quality chemical probes and eventual therapeutic leads are highly desirable. To expand the extent of known scaffolds targeting...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Marholz, Laura J., Wang, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475453/
https://www.ncbi.nlm.nih.gov/pubmed/25883088
http://dx.doi.org/10.1177/1087057115579637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475453/
https://www.ncbi.nlm.nih.gov/pubmed/25883088
http://dx.doi.org/10.1177/1087057115579637

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