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Novel Scaffolds of Cell-Active Histone Demethylase Inhibitors Identified from High-Throughput Screening
Jumonji C domain-containing histone demethylases (JHDMs) are epigenetic proteins capable of demethylating methylated lysine residues on histones proteins and for which high-quality chemical probes and eventual therapeutic leads are highly desirable. To expand the extent of known scaffolds targeting...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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SAGE Publications
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475453/ https://www.ncbi.nlm.nih.gov/pubmed/25883088 http://dx.doi.org/10.1177/1087057115579637 |