PI3K/Akt inhibition and down-regulation of BCRP re-sensitize MCF7 breast cancer cell line to mitoxantrone chemotherapy

OBJECTIVE(S): Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore,...

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Detalles Bibliográficos
Autores principales: Komeili-Movahhed, Tahereh, Fouladdel, Shamileh, Barzegar, Elmira, Atashpour, Shekoufeh, Hossein Ghahremani, Mohammad, Nasser Ostad, Seyed, Madjd, Zahra, Azizi, Ebrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475655/
https://www.ncbi.nlm.nih.gov/pubmed/26124933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475655/
https://www.ncbi.nlm.nih.gov/pubmed/26124933

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