Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving cytotoxic conformations of Cu, Zn superoxide dismutase (SOD1). A major challenge in understanding ALS disease pathology has been the identification and atomic-level characterization of these conformers. Here, we...

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Detalles Bibliográficos
Autores principales: Sekhar, Ashok, Rumfeldt, Jessica AO, Broom, Helen R, Doyle, Colleen M, Bouvignies, Guillaume, Meiering, Elizabeth M, Kay, Lewis E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475725/
https://www.ncbi.nlm.nih.gov/pubmed/26099300
http://dx.doi.org/10.7554/eLife.07296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475725/
https://www.ncbi.nlm.nih.gov/pubmed/26099300
http://dx.doi.org/10.7554/eLife.07296

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