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Formulation and characterization of 5-Fluorouracil enteric coated nanoparticles for sustained and localized release in treating colorectal cancer

5-Fluorouracil is used in the treatment of colorectal cancer along with oxaliplatin as first line treatment, but it is having lack of site specificity and poor therapeutic effect. Also toxic effects to healthy cells and unavailability of major proportion of drug at the colon region remain as limitat...

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Detalles Bibliográficos
Autores principales: Tummala, Shashank, Satish Kumar, M.N., Prakash, Ashwati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475851/
https://www.ncbi.nlm.nih.gov/pubmed/26106279
http://dx.doi.org/10.1016/j.jsps.2014.11.010