Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations

We assessed the utility of droplet digital PCR (ddPCR) to evaluate the potential of using circulating tumour DNA (ctDNA) as a post therapy monitoring tool in melanoma by comparing it to serum LDH levels and RECIST scores. ddPCR was shown to be reliable in distinguishing mutant from wild type alleles...

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Detalles Bibliográficos
Autores principales: Chang-Hao Tsao, Simon, Weiss, Jonathan, Hudson, Christopher, Christophi, Christopher, Cebon, Jonathan, Behren, Andreas, Dobrovic, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476039/
https://www.ncbi.nlm.nih.gov/pubmed/26095797
http://dx.doi.org/10.1038/srep11198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476039/
https://www.ncbi.nlm.nih.gov/pubmed/26095797
http://dx.doi.org/10.1038/srep11198

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