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Association of aberrant DNA methylation in Apc(min/+) mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq
BACKGROUND: Aberrant DNA methylation at the 5-carbon on cytosine residues (5mC) in CpG dinucleotides is probably the most extensively characterized epigenetic modification in colon cancer. It has been suggested that the loss of adenomatous polyposis coli (APC) function initiates tumorigenesis and th...
Autores principales: | Guo, Yue, Lee, Jong Hun, Shu, Limin, Huang, Ying, Li, Wenji, Zhang, Chengyue, Yang, Anne Yuqing, Boyanapalli, Sarandeep SS, Perekatt, Ansu, Hart, Ronald P, Verzi, Michael, Kong, Ah-Ng Tony |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476183/ https://www.ncbi.nlm.nih.gov/pubmed/26101583 http://dx.doi.org/10.1186/s13578-015-0013-2 |
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