Genomic prediction of complex human traits: relatedness, trait architecture and predictive meta-models

We explore the prediction of individuals' phenotypes for complex traits using genomic data. We compare several widely used prediction models, including Ridge Regression, LASSO and Elastic Nets estimated from cohort data, and polygenic risk scores constructed using published summary statistics f...

Descripción completa

Detalles Bibliográficos
Autores principales: Spiliopoulou, Athina, Nagy, Reka, Bermingham, Mairead L., Huffman, Jennifer E., Hayward, Caroline, Vitart, Veronique, Rudan, Igor, Campbell, Harry, Wright, Alan F., Wilson, James F., Pong-Wong, Ricardo, Agakov, Felix, Navarro, Pau, Haley, Chris S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Association Studies Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476450/
https://www.ncbi.nlm.nih.gov/pubmed/25918167
http://dx.doi.org/10.1093/hmg/ddv145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476450/
https://www.ncbi.nlm.nih.gov/pubmed/25918167
http://dx.doi.org/10.1093/hmg/ddv145

Ejemplares similares