Cargando…

The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum

The Moonwalker (Mwk) mouse is a model of dominantly inherited cerebellar ataxia caused by a gain-of-function mutation in the transient receptor potential (TRP) channel TRPC3. Here, we report impairments in dendritic growth and synapse formation early on during Purkinje cell development in the Mwk ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dulneva, Anna, Lee, Sheena, Oliver, Peter L., Di Gleria, Katalin, Kessler, Benedikt M., Davies, Kay E., Becker, Esther B. E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476454/ https://www.ncbi.nlm.nih.gov/pubmed/25908616 http://dx.doi.org/10.1093/hmg/ddv150

Ejemplares similares

The Moonwalker Mouse: New Insights into TRPC3 Function, Cerebellar Development, and Ataxia
por: Becker, Esther B. E.
Publicado: (2014)

Modeling Suggests TRPC3 Hydrogen Bonding and Not Phosphorylation Contributes to the Ataxia Phenotype of the Moonwalker Mouse
por: Hanson, Sonya M., et al.
Publicado: (2015)

Candidate Screening of the TRPC3 Gene in Cerebellar Ataxia
por: Becker, Esther B. E., et al.
Publicado: (2011)

Moonwalk with Your Eyes: A Pocket Field Guide
por: Plotner, Tammy
Publicado: (2010)

TRPC channel lipid specificity and mechanisms of lipid regulation
por: Beech, David J., et al.
Publicado: (2009)

Increasing the expression of calcium-permeable TRPC3 and TRPC7 channels enhances constitutive secretion
por: Lavender, Verna, et al.
Publicado: (2008)

What the ‘Moonwalk’ Illusion Reveals about the Perception of Relative Depth from Motion
por: Kromrey, Sarah, et al.
Publicado: (2011)

Olfactory stimuli and moonwalker SEZ neurons can drive backward locomotion in Drosophila
por: Israel, Shai, et al.
Publicado: (2022)

Intracellular calcium strongly potentiates agonist-activated TRPC5 channels
por: Blair, Nathaniel T., et al.
Publicado: (2009)

Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels
por: Cole, Bethan A., et al.
Publicado: (2023)

Mutants in Drosophila TRPC Channels Reduce Olfactory Sensitivity to Carbon Dioxide
por: Badsha, Farhath, et al.
Publicado: (2012)

Structure of the human lipid-gated cation channel TRPC3
por: Fan, Chen, et al.
Publicado: (2018)

Calcium permeability of transient receptor potential canonical (TRPC) 4 channels measured by TRPC4-GCaMP6s
por: Ko, Juyeon, et al.
Publicado: (2017)

Signal processing by T-type calcium channel interactions in the cerebellum
por: Engbers, Jordan D. T., et al.
Publicado: (2013)

TRPC-Mediated Current Is Not Involved in Endocannabinoid-Induced Short-Term Depression in Cerebellum
por: Chang, Wonseok, et al.
Publicado: (2012)

TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes
por: Streiff, Molly E., et al.
Publicado: (2022)

Lipid-independent control of endothelial and neuronal TRPC3 channels by light
por: Tiapko, Oleksandra, et al.
Publicado: (2019)

TRPC1 regulates calcium‐activated chloride channels in salivary gland cells
por: Sun, Yuyang, et al.
Publicado: (2015)

TRPC Channels in Cardiac Plasticity
por: Numaga-Tomita, Takuro, et al.
Publicado: (2020)

TRPC Channels in the SOCE Scenario
por: Lopez, Jose J., et al.
Publicado: (2020)

Corticolimbic Expression of TRPC4 and TRPC5 Channels in the Rodent Brain
por: Fowler, Melissa A., et al.
Publicado: (2007)

Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6
por: Liu, Lu, et al.
Publicado: (2020)

Structure of the mouse TRPC4 ion channel
por: Duan, Jingjing, et al.
Publicado: (2018)

TRPC channels in exercise-mimetic therapy
por: Numaga-Tomita, Takuro, et al.
Publicado: (2018)

TRPC3 Channels in Cardiac Fibrosis
por: Numaga-Tomita, Takuro, et al.
Publicado: (2017)

TRPC Channels in Proteinuric Kidney Diseases
por: Hall, Gentzon, et al.
Publicado: (2019)

The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
por: Sexton, Jane E., et al.
Publicado: (2016)

Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies
por: Wieder, Nicolas, et al.
Publicado: (2015)

TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response
por: Weber, Evan W., et al.
Publicado: (2015)

The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels
por: Kim, Hana, et al.
Publicado: (2012)

TRPC5 Channel Sensitivities to Antioxidants and Hydroxylated Stilbenes
por: Naylor, Jacqueline, et al.
Publicado: (2011)

The involvement of TRPC3 channels in sinoatrial arrhythmias
por: Ju, Yue-Kun, et al.
Publicado: (2015)

How TRPC Channels Modulate Hippocampal Function
por: Gualdani, Roberta, et al.
Publicado: (2020)

Polymodal roles of TRPC3 channel in the kidney
por: Khayyat, Naghmeh Hassanzadeh, et al.
Publicado: (2020)

Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells
por: Wong, Ching-On, et al.
Publicado: (2010)

Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes
por: Wen, Hairuo, et al.
Publicado: (2018)

Natural and synthetic flavonoid modulation of TRPC5 channels
por: Naylor, Jacqueline, et al.
Publicado: (2016)

Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1(−/-) mice
por: Greenberg, Harry Z.E., et al.
Publicado: (2019)

PIP(2) regulation of TRPC5 channel activation and desensitization
por: Ningoo, Mehek, et al.
Publicado: (2021)

Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes
por: Bartoli, Fiona, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_fv460hrk3h36rd1lff2cm8bd2q