A Transition Zone Showing Highly Discontinuous or Alternating Levels of Stem Cell and Proliferation Markers Characterizes the Development of PTEN-Haploinsufficient Colorectal Cancer

BACKGROUND: Stepwise acquisition of oncogene mutations and deletion/inactivation of tumor suppressor genes characterize the development of colorectal cancer (CRC). These genetic events interact with discrete morphologic transitions from hyperplastic mucosa to adenomatous areas, followed by in situ m...

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Detalles Bibliográficos
Autores principales: Arvai, Kevin J., Hsu, Ya-Hsuan, Lee, Lobin A., Jones, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476594/
https://www.ncbi.nlm.nih.gov/pubmed/26098881
http://dx.doi.org/10.1371/journal.pone.0131108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476594/
https://www.ncbi.nlm.nih.gov/pubmed/26098881
http://dx.doi.org/10.1371/journal.pone.0131108

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