Cargando…

Suppression of MAPK Signaling and Reversal of mTOR-Dependent MDR1-Associated Multidrug Resistance by 21α-Methylmelianodiol in Lung Cancer Cells

Lung cancer is the leading cause of cancer-related deaths worldwide and remains the most prevalent. Interplay between PI3K/AMPK/AKT and MAPK pathways is a crucial effector in lung cancer growth and progression. These signals transduction protein kinases serve as good therapeutic targets for non-smal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aldonza, Mark Borris Docdoc, Hong, Ji-Young, Bae, Song Yi, Song, Jayoung, Kim, Won Kyung, Oh, Jedo, Shin, Yoonho, Lee, Seung Ho, Lee, Sang Kook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476707/ https://www.ncbi.nlm.nih.gov/pubmed/26098947 http://dx.doi.org/10.1371/journal.pone.0127841

Ejemplares similares

Correction: Suppression of MAPK Signaling and Reversal of mTOR-Dependent MDR1-Associated Multidrug Resistance by 21α-Methylmelianodiol in Lung Cancer Cells
por: Aldonza, Mark Borris Docdoc, et al.
Publicado: (2015)

Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation
por: Aldonza, Mark Borris D., et al.
Publicado: (2016)

Paclitaxel-resistant cancer cell-derived secretomes elicit ABCB1-associated docetaxel cross-resistance and escape from apoptosis through FOXO3a-driven glycolytic regulation
por: Aldonza, Mark Borris D, et al.
Publicado: (2017)

mTOR and MAPK: from localized translation control to epilepsy
por: Pernice, Helena F., et al.
Publicado: (2016)

Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism
por: Rosina, Eleonora, et al.
Publicado: (2019)

Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish
por: Bu, Haisong, et al.
Publicado: (2021)

Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway
por: Kim, Jung-Min, et al.
Publicado: (2022)

Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents
por: Feng, Senling, et al.
Publicado: (2020)

5-Hydroxymethylfurfural Mitigates Lipopolysaccharide-Stimulated Inflammation via Suppression of MAPK, NF-κB and mTOR Activation in RAW 264.7 Cells
por: Kong, Fanhui, et al.
Publicado: (2019)

Comparison of characteristics and mortality in multidrug resistant (MDR) and non-MDR tuberculosis patients in China
por: Sun, Yanni, et al.
Publicado: (2015)

The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods
por: Wolfensberger, Aline, et al.
Publicado: (2019)

Multidrug resistance (mdr) genes in human cancer.
por: Nooter, K., et al.
Publicado: (1991)

Chemotherapy confers a conserved secondary tolerance to EGFR inhibition via AXL-mediated signaling bypass
por: Aldonza, Mark Borris D., et al.
Publicado: (2021)

Effects of Myristicin in Association with Chemotherapies on the Reversal of the Multidrug Resistance (MDR) Mechanism in Cancer
por: Seneme, Elisa Frederico, et al.
Publicado: (2022)

Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells
por: Miller, Aaron L, et al.
Publicado: (2007)

MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1
por: Brundage, Meghan E., et al.
Publicado: (2014)

6″-Debromohamacanthin A, a Bis (Indole) Alkaloid, Inhibits Angiogenesis by Targeting the VEGFR2-Mediated PI3K/AKT/mTOR Signaling Pathways
por: Kim, Gi Dae, et al.
Publicado: (2013)

Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells
por: Kang, Ji In, et al.
Publicado: (2015)

Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms
por: Aldonza, Mark Borris D., et al.
Publicado: (2020)

Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925
por: Yang, X, et al.
Publicado: (2014)

Predictors of Multidrug-Resistant Tuberculosis (MDR-TB) in Sudan
por: Ali, Monadil H., et al.
Publicado: (2019)

Combination of mTOR and MAPK Inhibitors—A Potential Way to Treat Renal Cell Carcinoma
por: Chauhan, Ashutosh, et al.
Publicado: (2016)

MAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade
por: Cai, Qinbo, et al.
Publicado: (2021)

Combination Treatment Targeting mTOR and MAPK Pathways Has Synergistic Activity in Multiple Myeloma
por: Sun, Kaiyan, et al.
Publicado: (2023)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Overcoming the Intrinsic Gefitinib-resistance via Downregulation of AXL in Non-small Cell Lung Cancer
por: Jeong, Inae, et al.
Publicado: (2019)

Reversing autism by targeting downstream mTOR signaling
por: Wang, Hansen, et al.
Publicado: (2013)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Magnolol as a Protective Antioxidant Alleviates Rotenone-Induced Oxidative Stress and Liver Damage through MAPK/mTOR/Nrf2 in Broilers
por: Peng, Weishi, et al.
Publicado: (2023)

A phase I study on the reversal of multidrug resistance (MDR) in vivo: nifedipine plus etoposide.
por: Philip, P. A., et al.
Publicado: (1992)

Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization
por: Kuger, Sebastian, et al.
Publicado: (2015)

Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer
por: Siegfried, Zahava, et al.
Publicado: (2013)

The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas
por: Du, Juan, et al.
Publicado: (2016)

Synergistic targeting of the PI3K/mTOR and MAPK/ERK pathways in Merkel cell carcinoma
por: Temblador, Arturo, et al.
Publicado: (2022)

Roles of mTOR Signaling in Brain Development
por: Lee, Da Yong
Publicado: (2015)

Regulation and expression of multidrug resistance (MDR) transcripts in the intestinal epithelium
por: Li, M, et al.
Publicado: (1999)

Novel strategies to prevent the development of multidrug resistance (MDR) in cancer
por: Wang, Jinglu, et al.
Publicado: (2017)

Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies
por: Catalano, Alessia, et al.
Publicado: (2022)

Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom Chlorophyllum molybdites, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities
por: Lee, Bum Soo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_aa89ft5o4gcdfa4bvhov4l4n0k