The Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB1*07:01

Idiosyncratic lapatinib-induced liver injury has been reported to be associated with human leukocyte antigen (HLA)-DRB1*07:01. In order to investigate its mechanism, interaction of lapatinib with HLA-DRB1*07:01 and its ligand peptide derived from tetanus toxoid, has been evaluated in vitro. Here we...

Descripción completa

Detalles Bibliográficos
Autores principales: Hirasawa, Makoto, Hagihara, Katsunobu, Okudaira, Noriko, Izumi, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476721/
https://www.ncbi.nlm.nih.gov/pubmed/26098642
http://dx.doi.org/10.1371/journal.pone.0130928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476721/
https://www.ncbi.nlm.nih.gov/pubmed/26098642
http://dx.doi.org/10.1371/journal.pone.0130928

Ejemplares similares