Cardiac Myocyte De Novo DNA Methyltransferases 3a/3b Are Dispensable for Cardiac Function and Remodeling after Chronic Pressure Overload in Mice

BACKGROUND: Recent studies reported altered DNA methylation in failing human hearts. This may suggest a role for de novo DNA methylation in the development of heart failure. Here, we tested whether cardiomyocyte-specific loss of de novo DNA methyltransferases Dnmt3a and Dnmt3b altered cardiac functi...

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Detalles Bibliográficos
Autores principales: Nührenberg, Thomas G., Hammann, Nils, Schnick, Tilman, Preißl, Sebastian, Witten, Anika, Stoll, Monika, Gilsbach, Ralf, Neumann, Franz-Josef, Hein, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476733/
https://www.ncbi.nlm.nih.gov/pubmed/26098432
http://dx.doi.org/10.1371/journal.pone.0131019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476733/
https://www.ncbi.nlm.nih.gov/pubmed/26098432
http://dx.doi.org/10.1371/journal.pone.0131019

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