Osteopontin Mediates an MZF1-TGF-β1-Dependent Transformation of Mesenchymal Stem Cells into Cancer Associated Fibroblasts in Breast Cancer

Interactions between tumor cells and cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TMEN) significantly influence cancer growth and metastasis. Transforming growth factor-β (TGF-β) is known to be a critical mediator of the CAF phenotype, and osteopontin (OPN) expression in tumor...

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Detalles Bibliográficos
Autores principales: Weber, Cynthia E., Kothari, Anai N., Wai, Philip Y., Li, Neill Y., Driver, Joseph, Zapf, Matthew A.C., Franzen, Carrie A., Gupta, Gopal N., Osipo, Clodio, Zlobin, Andrei, Syn, Wing Kin, Zhang, Jiwang, Kuo, Paul C., Mi, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476970/
https://www.ncbi.nlm.nih.gov/pubmed/25531323
http://dx.doi.org/10.1038/onc.2014.410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476970/
https://www.ncbi.nlm.nih.gov/pubmed/25531323
http://dx.doi.org/10.1038/onc.2014.410

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