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High-dose rifampicin kills persisters, shortens treatment duration, and reduces relapse rate in vitro and in vivo
Although high-dose rifampicin holds promise for improving tuberculosis control by potentially shortening treatment duration, these effects attributed to eradication of persistent bacteria are unclear. The presence of persistent Mycobacterium tuberculosis was examined using resuscitation promoting fa...
Autores principales: | Hu, Yanmin, Liu, Alexander, Ortega-Muro, Fatima, Alameda-Martin, Laura, Mitchison, Denis, Coates, Anthony |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477163/ https://www.ncbi.nlm.nih.gov/pubmed/26157437 http://dx.doi.org/10.3389/fmicb.2015.00641 |
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