Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia

Several lines of evidence implicate excess glucagon secretion in the elevated rates of hepatic glucose production (HGP), hyperglycemia, and ketosis characteristic of uncontrolled insulin-deficient diabetes (uDM), but whether hyperglucagonemia is required for hyperglycemia in this setting is unknown....

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Detalles Bibliográficos
Autores principales: Meek, Thomas H., Dorfman, Mauricio D., Matsen, Miles E., Fischer, Jonathan D., Cubelo, Alexis, Kumar, Monica R., Taborsky, Gerald J., Morton, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477352/
https://www.ncbi.nlm.nih.gov/pubmed/25633417
http://dx.doi.org/10.2337/db14-1562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477352/
https://www.ncbi.nlm.nih.gov/pubmed/25633417
http://dx.doi.org/10.2337/db14-1562

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