Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin

Insulin detemir (DET) reduces glycemia comparably to other long-acting insulin formulations but causes less weight gain. Insulin signaling in the brain is catabolic, reducing food intake. We hypothesized that DET reduces weight gain, relative to other insulins, owing to increased transport into the...

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Detalles Bibliográficos
Autores principales: Begg, Denovan P., May, Aaron A., Mul, Joram D., Liu, Min, D’Alessio, David A., Seeley, Randy J., Woods, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477354/
https://www.ncbi.nlm.nih.gov/pubmed/25667307
http://dx.doi.org/10.2337/db14-1364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477354/
https://www.ncbi.nlm.nih.gov/pubmed/25667307
http://dx.doi.org/10.2337/db14-1364

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