Engineering pH responsive fibronectin domains for biomedical applications

BACKGROUND: Engineered antibodies with pH responsive cell surface target antigen-binding affinities that decrease at the acidic pH (5.5-5.8) within the endosomes have been found to have reduced susceptibility to degradation within the lysosomes and increased serum half-life. Such pH responsive recom...

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Detalles Bibliográficos
Autores principales: Heinzelman, Pete, Krais, John, Ruben, Eliza, Pantazes, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477602/
https://www.ncbi.nlm.nih.gov/pubmed/26106447
http://dx.doi.org/10.1186/s13036-015-0004-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477602/
https://www.ncbi.nlm.nih.gov/pubmed/26106447
http://dx.doi.org/10.1186/s13036-015-0004-1

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