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Engineering pH responsive fibronectin domains for biomedical applications
BACKGROUND: Engineered antibodies with pH responsive cell surface target antigen-binding affinities that decrease at the acidic pH (5.5-5.8) within the endosomes have been found to have reduced susceptibility to degradation within the lysosomes and increased serum half-life. Such pH responsive recom...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477602/ https://www.ncbi.nlm.nih.gov/pubmed/26106447 http://dx.doi.org/10.1186/s13036-015-0004-1 |