A statistical framework for revealing signaling pathways perturbed by DNA variants

Much of the inter-individual variation in gene expression is triggered via perturbations of signaling networks by DNA variants. We present a novel probabilistic approach for identifying the particular pathways by which DNA variants perturb the signaling network. Our procedure, called PINE, relies on...

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Detalles Bibliográficos
Autores principales: Wilentzik, Roni, Gat-Viks, Irit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477643/
https://www.ncbi.nlm.nih.gov/pubmed/25765646
http://dx.doi.org/10.1093/nar/gkv203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477643/
https://www.ncbi.nlm.nih.gov/pubmed/25765646
http://dx.doi.org/10.1093/nar/gkv203

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