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A statistical framework for revealing signaling pathways perturbed by DNA variants
Much of the inter-individual variation in gene expression is triggered via perturbations of signaling networks by DNA variants. We present a novel probabilistic approach for identifying the particular pathways by which DNA variants perturb the signaling network. Our procedure, called PINE, relies on...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477643/ https://www.ncbi.nlm.nih.gov/pubmed/25765646 http://dx.doi.org/10.1093/nar/gkv203 |