Structural and sequencing analysis of local target DNA recognition by MLV integrase

Target-site selection by retroviral integrase (IN) proteins profoundly affects viral pathogenesis. We describe the solution nuclear magnetic resonance structure of the Moloney murine leukemia virus IN (M-MLV) C-terminal domain (CTD) and a structural homology model of the catalytic core domain (CCD)....

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Detalles Bibliográficos
Autores principales: Aiyer, Sriram, Rossi, Paolo, Malani, Nirav, Schneider, William M., Chandar, Ashwin, Bushman, Frederic D., Montelione, Gaetano T., Roth, Monica J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477651/
https://www.ncbi.nlm.nih.gov/pubmed/25969444
http://dx.doi.org/10.1093/nar/gkv410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477651/
https://www.ncbi.nlm.nih.gov/pubmed/25969444
http://dx.doi.org/10.1093/nar/gkv410

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