mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5

Homozygosity for a natural deletion variant of the HIV-coreceptor molecule CCR5, CCR5Δ32, confers resistance toward HIV infection. Allogeneic stem cell transplantation from a CCR5Δ32-homozygous donor has resulted in the first cure from HIV (‘Berlin patient’). Based thereon, genetic disruption of CCR...

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Detalles Bibliográficos
Autores principales: Mock, Ulrike, Machowicz, Rafał, Hauber, Ilona, Horn, Stefan, Abramowski, Pierre, Berdien, Belinda, Hauber, Joachim, Fehse, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477672/
https://www.ncbi.nlm.nih.gov/pubmed/25964300
http://dx.doi.org/10.1093/nar/gkv469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477672/
https://www.ncbi.nlm.nih.gov/pubmed/25964300
http://dx.doi.org/10.1093/nar/gkv469

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