Cargando…
Translational Upregulation of an Individual p21(Cip1) Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress
Multiple transcripts encode for the cell cycle inhibitor p21(Cip1). These transcripts produce identical proteins but differ in their 5’ untranslated regions (UTRs). Although several stresses that induce p21 have been characterized, the mechanisms regulating the individual transcript variants and the...
Autores principales: | Lehman, Stacey L., Cerniglia, George J., Johannes, Gregg J., Ye, Jiangbin, Ryeom, Sandra, Koumenis, Constantinos |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477940/ https://www.ncbi.nlm.nih.gov/pubmed/26102367 http://dx.doi.org/10.1371/journal.pgen.1005212 |
Ejemplares similares
-
Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma
por: Lehman, Stacey L., et al.
Publicado: (2015) -
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2
por: Ye, Jiangbin, et al.
Publicado: (2015) -
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage
por: Bobrovnikova-Marjon, Ekaterina, et al.
Publicado: (2010) -
GCN sensitive protein translation in yeast
por: Barr, William A., et al.
Publicado: (2020) -
YueF Overexpression Inhibits Cell Proliferation Partly through p21(WAF1/Cip1) Upregulation in Renal Cell Carcinoma
por: Huang, Hsuan-Wei, et al.
Publicado: (2011)