Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells

NF-κB is an important regulator of both differentiation and function of lineage-committed hematopoietic cells. Targeted deletion of IκB kinase (IKK) β results in altered cytokine signaling and marked neutrophilia. To investigate the role of IKKβ in regulation of hematopoiesis, we employed Mx1-Cre me...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Li, Li, Baldwin, Albert S., Friedman, Alan D., Paz-Priel, Ido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477978/
https://www.ncbi.nlm.nih.gov/pubmed/26102347
http://dx.doi.org/10.1371/journal.pone.0130441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477978/
https://www.ncbi.nlm.nih.gov/pubmed/26102347
http://dx.doi.org/10.1371/journal.pone.0130441

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