Targeted DNA degradation using a CRISPR device stably carried in the host genome

Once an engineered organism completes its task, it is useful to degrade the associated DNA to reduce environmental release and protect intellectual property. Here we present a genetically encoded device (DNAi) that responds to a transcriptional input and degrades user-defined DNA. This enables engin...

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Detalles Bibliográficos
Autores principales: Caliando, Brian J., Voigt, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479009/
https://www.ncbi.nlm.nih.gov/pubmed/25988366
http://dx.doi.org/10.1038/ncomms7989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479009/
https://www.ncbi.nlm.nih.gov/pubmed/25988366
http://dx.doi.org/10.1038/ncomms7989

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