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Targeted DNA degradation using a CRISPR device stably carried in the host genome
Once an engineered organism completes its task, it is useful to degrade the associated DNA to reduce environmental release and protect intellectual property. Here we present a genetically encoded device (DNAi) that responds to a transcriptional input and degrades user-defined DNA. This enables engin...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Pub. Group
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479009/ https://www.ncbi.nlm.nih.gov/pubmed/25988366 http://dx.doi.org/10.1038/ncomms7989 |