AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial

BACKGROUND: Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine, and difficulties administering 14 days of amphotericin B are key drivers of this mortality. Novel tr...

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Detalles Bibliográficos
Autores principales: Molefi, Mooketsi, Chofle, Awilly A., Molloy, Síle F., Kalluvya, Samuel, Changalucha, John M., Cainelli, Francesca, Leeme, Tshepo, Lekwape, Nametso, Goldberg, Drew W., Haverkamp, Miriam, Bisson, Gregory P., Perfect, John R., Letang, Emili, Fenner, Lukas, Meintjes, Graeme, Burton, Rosie, Makadzange, Tariro, Ndhlovu, Chiratidzo E., Hope, William, Harrison, Thomas S., Jarvis, Joseph N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479349/
https://www.ncbi.nlm.nih.gov/pubmed/26081985
http://dx.doi.org/10.1186/s13063-015-0799-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479349/
https://www.ncbi.nlm.nih.gov/pubmed/26081985
http://dx.doi.org/10.1186/s13063-015-0799-6

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