HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures

Cervical cancer is a multi-stage disease caused by human papillomaviruses (HPV) infection of cervical epithelial cells, but the mechanisms regulating disease progression are not clearly defined. Using 3-dimensional organotypic cultures, we demonstrate that HPV16 E6 and E7 proteins alter the secretom...

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Detalles Bibliográficos
Autores principales: Pickard, Adam, McDade, Simon S., McFarland, Marie, McCluggage, W. Glenn, Wheeler, Cosette M., McCance, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479471/
https://www.ncbi.nlm.nih.gov/pubmed/26107517
http://dx.doi.org/10.1371/journal.ppat.1004988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479471/
https://www.ncbi.nlm.nih.gov/pubmed/26107517
http://dx.doi.org/10.1371/journal.ppat.1004988

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