Differential involvement of Ras-GRF1 and Ras-GRF2 in L-DOPA-induced dyskinesia

OBJECTIVE: Recent findings have shown that pharmacogenetic manipulations of the Ras-ERK pathway provide a therapeutic means to tackle l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID). First, we investigated whether a prolonged l-DOPA treatment differentially affected ERK signaling in m...

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Detalles Bibliográficos
Autores principales: Bido, Simone, Solari, Nicola, Indrigo, Marzia, D’Antoni, Angela, Brambilla, Riccardo, Morari, Michele, Fasano, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479526/
https://www.ncbi.nlm.nih.gov/pubmed/26125041
http://dx.doi.org/10.1002/acn3.202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479526/
https://www.ncbi.nlm.nih.gov/pubmed/26125041
http://dx.doi.org/10.1002/acn3.202

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