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Torin 1 partially corrects vigabatrin-induced mitochondrial increase in mouse
Recent findings in mice with targeted deletion of the GABA-metabolic enzyme succinic semialdehyde dehydrogenase revealed a new role for supraphysiological GABA (4-aminobutyric acid) in the activation of the mechanistic target of rapamycin (mTOR) that results in disruption of endogenous mitophagy. Em...
Autores principales: | Vogel, Kara R, Ainslie, Garrett R, Jansen, Erwin E W, Salomons, Gajja S, Gibson, K Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479529/ https://www.ncbi.nlm.nih.gov/pubmed/26125044 http://dx.doi.org/10.1002/acn3.200 |
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