Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein

Two licensed serogroup B meningococcal vaccines contain factor H binding protein (FHbp). The antigen specifically binds human FH, which downregulates complement. In wild-type mice whose mouse FH does not bind to FHbp vaccines, the serum anti-FHbp antibody response inhibited binding of human FH to FH...

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Detalles Bibliográficos
Autores principales: Beernink, Peter T., Giuntini, Serena, Costa, Isabella, Lucas, Alexander H., Granoff, Dan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479705/
https://www.ncbi.nlm.nih.gov/pubmed/26106082
http://dx.doi.org/10.1128/mBio.00842-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479705/
https://www.ncbi.nlm.nih.gov/pubmed/26106082
http://dx.doi.org/10.1128/mBio.00842-15

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