MAF1 represses CDKN1A through a Pol III-dependent mechanism

MAF1 represses Pol III-mediated transcription by interfering with TFIIIB and Pol III. Herein, we found that MAF1 knockdown induced CDKN1A transcription and chromatin looping concurrently with Pol III recruitment. Simultaneous knockdown of MAF1 with Pol III or BRF1 (subunit of TFIIIB) diminished the...

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Detalles Bibliográficos
Autores principales: Lee, Yu-Ling, Li, Yuan-Ching, Su, Chia-Hsin, Chiao, Chun-Hui, Lin, I-Hsuan, Hsu, Ming-Ta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480132/
https://www.ncbi.nlm.nih.gov/pubmed/26067234
http://dx.doi.org/10.7554/eLife.06283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480132/
https://www.ncbi.nlm.nih.gov/pubmed/26067234
http://dx.doi.org/10.7554/eLife.06283

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