Cargando…

MAF1 represses CDKN1A through a Pol III-dependent mechanism

MAF1 represses Pol III-mediated transcription by interfering with TFIIIB and Pol III. Herein, we found that MAF1 knockdown induced CDKN1A transcription and chromatin looping concurrently with Pol III recruitment. Simultaneous knockdown of MAF1 with Pol III or BRF1 (subunit of TFIIIB) diminished the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Yu-Ling, Li, Yuan-Ching, Su, Chia-Hsin, Chiao, Chun-Hui, Lin, I-Hsuan, Hsu, Ming-Ta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480132/ https://www.ncbi.nlm.nih.gov/pubmed/26067234 http://dx.doi.org/10.7554/eLife.06283

Ejemplares similares

Maf1 and Repression of RNA Polymerase III-Mediated Transcription Drive Adipocyte Differentiation
por: Chen, Chun-Yuan, et al.
Publicado: (2018)

Structural basis for RNA polymerase III transcription repression by Maf1
por: Vorländer, Matthias K., et al.
Publicado: (2020)

Screening and identification of NOTCH1, CDKN2A, and NOS3 as differentially expressed autophagy-related genes in erectile dysfunction
por: Luo, Chao, et al.
Publicado: (2021)

PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression
por: Oler, Andrew J, et al.
Publicado: (2012)

Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons
por: Jonkers, Iris, et al.
Publicado: (2014)

Long non‑coding RNA L13Rik promotes high glucose-induced mesangial cell hypertrophy and matrix protein expression by regulating miR-2861/CDKN1B axis
por: Sun, Linlin, et al.
Publicado: (2023)

Theacrine alleviates sepsis-induced acute kidney injury by repressing the activation of NLRP3/Caspase-1 inflammasome
por: Yang, Maoxian, et al.
Publicado: (2022)

MicroRNA-mediated repression of nonsense mRNAs
por: Zhao, Ya, et al.
Publicado: (2014)

Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7
por: Beusch, Irene, et al.
Publicado: (2017)

MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass
por: Phillips, Ellen, et al.
Publicado: (2022)

Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression
por: Andreev, Dmitry E, et al.
Publicado: (2015)

Expression, refolding and spectroscopic characterization of fibronectin type III (FnIII)-homology domains derived from human fibronectin leucine rich transmembrane protein (FLRT)-1, -2, and -3
por: Yang, Lila, et al.
Publicado: (2017)

The structure of the core NuRD repression complex provides insights into its interaction with chromatin
por: Millard, Christopher J, et al.
Publicado: (2016)

Translation repression via modulation of the cytoplasmic poly(A)-binding protein in the inflammatory response
por: Zhang, Xu, et al.
Publicado: (2017)

MAF2 Is Regulated by Temperature-Dependent Splicing and Represses Flowering at Low Temperatures in Parallel with FLM
por: Airoldi, Chiara A., et al.
Publicado: (2015)

RNA Processing Factors Swd2.2 and Sen1 Antagonize RNA Pol III-Dependent Transcription and the Localization of Condensin at Pol III Genes
por: Legros, Pénélope, et al.
Publicado: (2014)

Glycolytic flux in Saccharomyces cerevisiae is dependent on RNA polymerase III and its negative regulator Maf1
por: Szatkowska, Roza, et al.
Publicado: (2019)

ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis
por: Tang, Shaogeng, et al.
Publicado: (2016)

Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing
por: Wongpalee, Somsakul Pop, et al.
Publicado: (2016)

N-acetylcysteine alleviates PCB52-induced hepatotoxicity by repressing oxidative stress and inflammatory responses
por: Zhou, Wen-Tao, et al.
Publicado: (2020)

Paeoniflorin improves functional recovery through repressing neuroinflammation and facilitating neurogenesis in rat stroke model
por: Tang, Hongli, et al.
Publicado: (2021)

Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes
por: Bonasio, Roberto, et al.
Publicado: (2014)

Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes Cdkn1a and Cdkn1b
por: Lüdtke, Timo H-W., et al.
Publicado: (2013)

The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression
por: Bian, Chunjing, et al.
Publicado: (2015)

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance
por: Bonhoure, Nicolas, et al.
Publicado: (2015)

MAF1 is a chronic repressor of RNA polymerase III transcription in the mouse
por: Bonhoure, Nicolas, et al.
Publicado: (2020)

Correction: The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression
por: Bian, Chunjing, et al.
Publicado: (2015)

PUM1 represses CDKN1B translation and contributes to prostate cancer progression
por: Li, Xin, et al.
Publicado: (2021)

Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest
por: Orioli, Andrea, et al.
Publicado: (2016)

A Role of Miz-1 in Gfi-1-Mediated Transcriptional Repression of CDKN1A
por: Liu, Qingquan, et al.
Publicado: (2010)

A shunt pathway limits the CaaX processing of Hsp40 Ydj1p and regulates Ydj1p-dependent phenotypes
por: Hildebrandt, Emily R, et al.
Publicado: (2016)

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization
por: Papp, Stephanie J, et al.
Publicado: (2015)

B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan
por: Praissman, Jeremy L, et al.
Publicado: (2014)

CAV1 alleviated CaOx stones formation via suppressing autophagy-dependent ferroptosis
por: Yang, Yuanyuan, et al.
Publicado: (2022)

Ctf4 organizes sister replisomes and Pol α into a replication factory
por: Yuan, Zuanning, et al.
Publicado: (2019)

TCF-1 limits the formation of Tc17 cells via repression of the MAF–RORγt axis
por: Mielke, Lisa A., et al.
Publicado: (2019)

Inhibitory effect and mechanism of action (MOA) of hirsutine on the proliferation of T-cell leukemia Jurkat clone E6-1 cells
por: Meng, Jie, et al.
Publicado: (2021)

RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells
por: Hsin, Jing-Ping, et al.
Publicado: (2014)

Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine
por: Jadhav, Unmesh, et al.
Publicado: (2016)

LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner
por: Kramer, Holly B., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_r460k72vr69u83idbjmvk73ogp