Indole trimers with antibacterial activity against Gram-positive organisms produced using combinatorial biocatalysis

The I100V isoform of toluene-4-monooxygenase was used to catalyze the oxidative polymerization of anthranil and various indoles under mildly acidic conditions, favoring the production of trimers. Compounds produced in sufficient yield were purified and tested for their ability to inhibit the growth...

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Detalles Bibliográficos
Autores principales: McClay, Kevin, Mehboob, Shahila, Yu, Jerry, Santarsiero, Bernard D, Deng, Jiangping, Cook, James L, Jeong, Hyunyoung, Johnson, Michael E, Steffan, Robert J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480272/
https://www.ncbi.nlm.nih.gov/pubmed/26112315
http://dx.doi.org/10.1186/s13568-015-0125-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480272/
https://www.ncbi.nlm.nih.gov/pubmed/26112315
http://dx.doi.org/10.1186/s13568-015-0125-4

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