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Indole trimers with antibacterial activity against Gram-positive organisms produced using combinatorial biocatalysis
The I100V isoform of toluene-4-monooxygenase was used to catalyze the oxidative polymerization of anthranil and various indoles under mildly acidic conditions, favoring the production of trimers. Compounds produced in sufficient yield were purified and tested for their ability to inhibit the growth...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480272/ https://www.ncbi.nlm.nih.gov/pubmed/26112315 http://dx.doi.org/10.1186/s13568-015-0125-4 |